UnityPoint Health reduced maternal sepsis mortality from 3.2% to 0% by adapting its adult sepsis care path for pregnant and postpartum patients, enabling earlier treatment and reducing the risk of lifelong complications for 133 patients. The organization estimates that its program saves four moms' lives each year.

Sentara Health reduced hospital-onset MRSA cases by nearly 50% after pairing an automated MRSA risk score in Epic with targeted decolonization workflows. It has avoided an estimated $1.18 million in infection-related costs to date and is on track to reach more than $2 million in savings over five years.

Nemours Children’s Health’s Asthma Community Health Worker Program in Delaware demonstrates how home visits led by community health workers can improve pediatric asthma outcomes by addressing what clinic visits can’t: environmental triggers, medication routines, and social barriers. In its first 18 months, the program enrolled 138 children, completed more than 700 home visits, and saw 83.5% of graduated patients meaningfully improve their asthma control test scores.

Fourteen hospitals across the Netherlands that use Epic collaborated with the Perined national registry to standardize newborn delivery documentation, reducing missing data by up to 72% and decreasing documentation time by 25–30%. The shared approach improved data quality to support maternal and infant health research and established a sustainable model for cross-organization collaboration.