Researchers at the Royal Melbourne Hospital used Epic to study treatment methods for hypophosphatemia, an electrolyte disorder. They conducted the first pragmatic randomized control study conducted entirely within the Epic system in Australia and found that the mean cost per patient was 10-fold less with enteral treatment than with IV treatment, CO2 emissions were 60-fold less, and treatment produced 96% less waste measured by weight.

AdventHealth dedicates four hours per month for nurses in its Service Line Expert Extenders program to grow their EHR skills and share knowledge with their units. With part-time extenders in 85% of units, nurses saved an average of 28 minutes per shift on documentation, and nurse turnover was 21% lower when extenders participated in the Professional Excellence Program.

Lee Health developed a sepsis prevention and survivorship program that uses Epic's sepsis predictive model to identify at-risk patients, an order set to help the care team follow best practices, and remote patient monitoring to support patients after discharge. The organization reduced the average length of stay for patients with sepsis by two days and reduced mortality by 18%—representing 110 lives saved in one year.

Through a grant-funded partnership with the NYC Health Department, NYC Health + Hospitals increased referrals to free early intervention services for children with developmental delays. Employing referral forms in Epic and community health workers, the organization improved the referral rate by 30%. Children received services starting at 18-23 months on average, compared with the New York City average of 24-29 months.